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Its name may be misleading (there are, in fact, sixteen rooms), but everything else about this two-year-old hotel is textbook boutique. The suites—in small, medium and large (the first two categories are quite small, so book the large) sizes, and priced accordingly—were designed by the hotel’s owner, an architect. There’s a relaxing living room/lobby area with bare pine flooring, sofas and a flat-screen television, and a lovely central courtyard and 1,500-square-foot rooftop terrace with a fireplace and a Jacuzzi. Rooms (several of which have their own Jacuzzis) are furnished with wenge-wood furniture, llama-wool rugs, flat-screen TVs and comfy cotton and sateen sheets and, in winter, corduroy bedspreads, though the property’s main attribute is undoubtedly its location, smack-dab in the middle of Palermo SoHo’s highest concentration of trendy clothing and home-furnishings shops, bars and cafés. Rooms from $105.

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If you value hip, in-the-know recommendations as much as you do cozy, well-designed personal quarters, you’ll be comfortable at this hotel. Owned by a glamorous PR exec and her record-producer husband, the airy three-story Home’s common areas are decked in vintage French wallpaper, Scandinavian furniture and Saarinen Tulip tables and chairs. The seventeen rooms come with what staff calls “the right simple luxuries” (plush bathrobes, walk-in showers and luxurious bedding, as well as large windows and/or terraces overlooking the infinity pool and lush garden area or the tree-lined street), and three suites have private Jacuzzis. The crown jewel is the Garden Suite, with waterside floor-to-ceiling windows and a flower-filled roof terrace. Don’t miss treatments at the pampering spa or the weekly Sunday afternoon asado (traditional Argentine barbecue) at the Resto-Bar. Rooms from $115.

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Insiders may say “Palermo Viejo is the new Las Canitas,” but the latter, a pulsating nightlife district, is still a hot-spot neighborhood. The eleven densely furnished rooms at Las Canita’s newest, most talked-about hotel are small but clean, bright and appointed with a mix of antiques and patterned blankets and pillows. An idyllic garden serves as the social hub of the hotel, as do the sleek wine bar and living room, complete with a fireplace and a sparkling chandelier. While there’s no pool, there is an outdoor deck and hot tub. Ask for one of two deluxe rooms, at the back of the hotel, and a bit removed from the noise (Finisterra has a busy restaurant on either side). Rooms from $135.