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D.O.M
After a five-year stint in Europe, chef Alex Atala returned to São Paulo in 1999 with a mission to change the way Latin America eats. His restaurant, D.O.M., is now regarded as the best restaurant in South America, and is known for the nouveau-Brazilian cuisine that has seen a resurgence in recent years. Blending European cooking techniques with Brazilian flavors, Atala has successfully changed the São Paulo culinary landscape, pushing chefs towards more sustainable, local ingredients that benefit the regional community.
Due Cuochi
Casual yet refined, Due Cuochi is the go-to spot in Italian-heavy São Paulo for motherland comfort food. The kitchen changes menus frequently, but the black truffled egg yolk ravioli is a signature dish. Simple, fresh ingredients are the rule: the bavete with shrimp and calamari, for example, boasts nothing more beyond tomato and basil—and it's beautiful. You won't find better Italian for the price.
Note: The restaurant has several outposts in São Paulo.
Kan
Behind an understated door inside a ubiquitous shopping arcade is the simple domain of Japanese sushi chef Keisuke Egashira, a newcomer in Brazil armed with 23 years of Tokyo experience under his apron. He barely speaks Portuguese at all, but Egashira's fish quickly garnered top honors in a city with no shortage of amazing Japanese experiences. There are just eight seats at the sushi bar (and a few scattered tables) and the menu is entirely in Japanese. Can you say, Omakase?
Kinoshita
With the largest Japanese population outside of Japan, São Paulo is known for great sushi, with Kinoshita leading the pack. Hokkaido-born, Rio-raised chef Tsuyoshi Murakami is regarded as one of South America’s best Japanese chefs, and his Brazil-influenced cooking draws the city’s well heeled. Order off the delicious tasting menu, or let chatty, boisterous chef make you one of his custom creations.
Maní
Mocotó/Esquina Mocotó
Arguably Brazil's most important up and coming chef, Rodrigo Oliviera, upped the ante on his father's simple restaurant, transforming it into a place that the Paulistano gourmet elite (and everyone else) was willing to travel deep into the city's gastronomy-scarce North Zone to eat. At Mocotó, hearty (read: meat heavy) Northeastern Brazilian cuisine is chased by long list of artisan cachaças; next door at higher-end Esquina Mocotó, Oliveria's less traditional creative juices flow. Either way, it's worth both the trip to Vila Medeiros and the wait – Oliveira only takes reservations at Esquina.
Skye Bar
The rooftop bar on the Hotel Unique is a perennial hot spot for the city’s most beautiful and fashionable. The party here starts late and goes until morning—and the occasional reveler ending up in the red pool.
Spot
This trendy restaurant draws a very chic crowd who come for its ambience and reliable continental cuisine.
Trattoria Fasano
One of many properties owned by the Fasanos, this tony Italian restaurant is located in their chic hotel Fasano São Paulo. With a vast dining room, fancy ambience, fantastic cuisine and attentive service, this is the best Italian restaurant in the city.
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